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Tuning Prisms
Tuning Prisms steer a transmutation in the Horadric Cube towards one kind of affix: Aggressive for Offensive, Protector's for Defensive, Resourceful for Resource, Pragmatic for Mobility and Utility, Chromatic for Resistances and Adept's for Skill and Core Stat affixes. The Entropic and Kullean prisms change the outcome of a Transfiguration instead.
Boss materials
Materials such as Living Steel and the Pincushioned Doll are used in the Horadric Cube to transmute items from that boss's Hoard. Older ones that have lost their connection to their boss can be turned into Lair Keys at the Alchemist.
Resplendent Spark and the rest
The Resplendent Spark is used to forge or craft Mythic Uniques. Other materials here serve their own systems, for example Corrupted Roots for the Tree of Whispers and Aethereal Ash for concoctions against the Infernal Hordes.
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Diablo 4 Materials Questions, Answered
What does a Tuning Prism do?
It makes a Horadric Cube transmutation target one kind of affix, such as Offensive, Defensive or Resistance affixes.
What is a Resplendent Spark used for?
Forging a Mythic Unique Cache at the Blacksmith, or crafting a Mythic Unique at the Jeweler.
